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Obstructive Uropathy

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What You Will Learn

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    • Obstructive Uropathy: Impedance in the flow of urine anywhere along the urinary tract
    • Obstructive Nephropathy: Obstructive uropathy with derangement in renal function


    Acute Chronic
    Unilateral AU (1:1,000) CU (5:1,000)
    Bilateral AB (5:10,000) CB (1:1,000)

    Acute Unilateral

    • Kidney and ureteric stones
    • Ureteric injuries
      • TAH
      • APR
      • Ureteral manipulative procedures
      • VVF repair
      • etc
    • Ureteric tumours
    • Blood clots

    Chronic Unilateral

    • Kidney stones
    • PUJ obstruction
    • Ureteric stones, tumours, strictures, megaureter
    • Vesicoureteric reflux
    • Invading tumours of adjacent organs
      • Cervix
      • Ovary
      • Bladder
      • Rectum
      • Prostate
      • Uterus
    • Retroperitoneal tumours
    • Retroperitoneal fibrosis
    • Injuries
      • TAH, APR, CS, VVF

    Acute Bilateral

    • Surgical injuries
      • TAH, APR, CS, VVF repair
    • Prostate
      • BPH, prostate cancer, prostatitis, prostatic abscess
    • Urethra
      • Trauma, strictures, stones
    • Bladder
      • Tumours, cystoceles, retroverted uterus, pregnancy
    • Clots, papillary necrosis
    • Cervix cancer
    • Posterior urethral valves
    • Meatal stenosis

    Chronic Bilateral

    • PUJ obstruction
    • Vesicoureteric reflux or obstruction
    • Posterior urethral valves
    • Meatal stenosis
    • Prostate
    • Urethra
    • Cervix, uterus

    History

    • Bio data viz age, sex, occupation
    • Loin pain, oliguria, anuria, oedema, hiccups
    • Hesitancy, poor urine stream, straining, intermittency, incomplete bladder emptying, and retention
    • 5Cs (complaint, course, cause, complications, care)
    • Medication history
      • Antihistamines, antipsychotics, antidepressants
      • Ethylene glycol, indinavir, methotrexate, phenylbutazone, or sulfonamides
      • Methysergide or other natural-occurring ergotamines
    • Occupational exposure history
      • Textile manufacturers, shipyard workers, roofers, or asbestos miners (retroperitoneal fibrosis)
      • Textile workers, rubber manufacturing workers, leather workers, painters, hairdressers, drill press workers (bladder cancer)
    • Review of other systems - very important

    Physical Examination

    • Signs of dehydration and intravascular volume depletion
    • Peripheral edema, hypertension, signs of congestive heart failure
    • Palpable kidney or bladder
    • Enlargement of pelvic organs (e.g., prostate, uterus)
    • Examination of external urethra for phimosis, meatal stenosis

    Laboratory

    • FBC
    • E&U, Cr
    • Urinalysis
    • Urine mcs
    • FBS
    • PSA

    Imaging

    • Abdominal ultrasound
    • Abdominal CT scan
      • CT urography
    • MRI urography
    • Intravenous urography (IVU)
    • Micturating cystourethrogram
    • Retrograde urethrogram
    • Renal nuclear scan
    • Radionuclear cystography

    note

    Renal Nuclear Scan

    • DSMA (Technetium Tc 99m dimercaptosuccinic acid) for cortical or parenchymal structure: pyelonephritis, scar, and solid renal masses. Determining relative (split) renal function, renal ectopia, infarction, horseshoe kidney, thrombosis, acute renal failure, MCDKs, and trauma
    • 99m Tc-MAG3 (Technetium Tc 99m mercaptoacetythiglycine)
    • Dynamic or functional scintigraphy
    • Diuretic renal scintigraphy
    • Post-transplant evaluation
    • Obstruction

    Temporary Relief

    • Urethral catheter
    • Suprapubic catheter
    • Ureteric stent (Double J stent)
    • Urethrostomy
    • Ureterostomy: Tubed, non-tubed
    • Nephrostomy

    Permanent Correction

    • Surgery - depends on the aetiology
    • Urethroplasty
    • Prostatectomy
    • Others:
      • Pyeloplasty
      • Nephrectomy
      • Etc
    • Radiotherapy for malignant obstruction

    • Recurrent UTI
    • Loss of kidney
    • Renal failure
    • Hypertension
    • Stone formation
    • Post-decompressive hematuria
    • Post-obstructive diuresis
      • 200ml/hour

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    Practice Questions

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